This is part of the Med in Small Doses series, which aims to give you a snapshot of a disease or disorder. For information about the series, or common abbreviations click here.
80% of Adult Brain Tumours. Astrocyte Tumour. 40-60yo.
PATHO: Ionising Radiaiton & Familial Syndromes are RFs. A/W Neurofibromatosis.
Low Grade: p53, PDGF-α. High Grade: RB, p16/CDKNaA, & unknown tumour suppressor gene.
Produce oedema → fuzzy contrast border, central necrosis.
Types: Infiltrating & Non-infiltrating Astrocytoma.
- Analplastic A: ↑ density, ↑ nuclear polymorphism
- Glioblastoma Multiforme (GBM): necrosis & vascular proliferation; can be firm & white OR soft & yellow, glomeruloid bodies.
CFs: Pain, seizure, neuro deficits (location dependant), features of ↑ ICP (headaches, vomiting, visual Δs).
Infants: fullness of frontanelle, dev.delay, hydrocephalus.
Ix: MRI, Myelography, EEG, PET, Biopsy
Tx: Surgical resection (5yr survival over 90% with well resected), XRT, Chemo (high grade, recurrent)
Anticonvulsants (seizures), Mannitol (↓ICP), PT (↑Motor function), OT